Article:Chagas disease: "the new HIV/AIDS of the Americas"

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This page is the ScienceSource HTML version of the scholarly article described at Its title is Chagas disease: "the new HIV/AIDS of the Americas" and the publication date was 2012. The initial author is Peter J. Hotez.

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Journal Information

Title: PLoS Neglected Tropical Diseases

Chagas Disease: “The New HIV/AIDS of the Americas”

  • Peter J. Hotez
  • Eric Dumonteil
  • Laila Woc-Colburn
  • Jose A. Serpa
  • Sarah Bezek
  • Morven S. Edwards
  • Camden J. Hallmark
  • Laura W. Musselwhite
  • Benjamin J. Flink
  • Maria Elena Bottazzi

[1]Departments of Pediatrics and Molecular Virology & Microbiology, and Sabin Vaccine Institute and Texas Children's Center for Vaccine Development, Baylor College of Medicine, Houston, Texas, United States of America

[2]National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

[3]Laboratorio de Parasitologia, Centro de Investigaciones Regionales “Dr Hideyo Noguchi”, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico

[4]Section of Infectious Diseases, Department of Internal Medicine, Baylor College of Medicine, Houston, Texas, United States of America

[5]Department of Emergency Medicine, Baylor College of Medicine, Houston, Texas, United States of America

[6]Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America

[7]Houston Department of Health and Human Services, Houston, Texas, United States of America

[8]Duke University School of Medicine, Durham, North Carolina, United States of America

Publication date (collection): 5/2012

Publication date (epub): 5/2012


Endemic Chagas disease has emerged as an important health disparity in the Americas. As a result, we face a situation in both Latin America and the US that bears a resemblance to the early years of the HIV/AIDS pandemic.

Neglected tropical diseases (NTDs) are among the most common conditions afflicting the estimated 99 million people who live on less than US$2 per day in the Latin American and Caribbean (LAC) region [1]. Almost all of the “bottom 100 million” living in the Americas suffer from at least one NTD [1], and according to some estimates, the NTDs cause a burden of disease in the LAC region that closely approximates or even exceeds that resulting from HIV/AIDS [2]. Chagas disease (American trypanosomiasis) is a vector-borne disease and a leading cause of the deaths and disability-adjusted life years (DALYs) lost that result from NTDs in the LAC region [2]. With approximately 10 million people living with Chagas disease, this condition is one of the most common NTDs affecting the bottom 100 million in the region, a prevalence exceeded only by hookworm and other soil-transmitted helminth infections [1], [2]. Moreover, among the NTDs in the Americas, Chagas disease ranks near the top in terms of annual deaths and DALYs lost [1], [2].

While most of the world's cases of Chagas disease occur in the LAC region, there is increasing recognition that many people with Trypanosoma cruzi infection also live in the US and Europe [3]. In practical terms, the “globalization” of Chagas translates to up to 1 million cases in the US alone, with an especially high burden of disease in Texas and along the Gulf coast [4], [5], although other estimates suggest that there are approximately 300,000 cases in the US [6], in addition to thousands of cases documented in Canada, Europe, Australia, and Japan [3]. Among those living with Chagas disease around the world today, 20%–30% (roughly 2–3 million people) are either currently suffering from Chagasic cardiomyopathy or will develop this clinical sequela [7]. Chagasic cardiomyopathy is a highly debilitating condition characterized by cardiac arrhythmias, heart failure, and risk of sudden death from ventricular fibrillation or tachycardia or thromboembolic events [7]. Another estimate suggests that up to 5.4 million people living today will develop Chagasic cardiomyopathy [8], [9]. Damage to the gastrointestinal tract can also produce debilitating megaesophagus and megacolon [7].

There are a number of striking similarities between people living with Chagas disease and people living with HIV/AIDS, particularly for those with HIV/AIDS who contracted the disease in the first two decades of the HIV/AIDS epidemic. Both diseases are health disparities, disproportionately affecting people living in poverty [1], [2]. Both are chronic conditions requiring prolonged treatment courses: a lifetime of antiretroviral therapy for HIV/AIDS patients, and one to three months of therapy for those with Chagas disease [7]. Treatment for HIV/AIDS is lifesaving, although it seldom if ever results in cure, while for Chagas disease, the treatment has proven efficacy only for the acute stages of the infection or in children up to 12 years of age during the early chronic phase of the infection [10]. For both diseases the treatment is expensive—in the case of Chagas disease, the expected cost of treatment per patient year is $1,028, with lifetime costs averaging $11,619 per patient [11]. Exacerbating costs, Chagas disease itself is a serious opportunistic infection of people living with HIV/AIDS, and is associated with meningoencephalitis, cerebral lesions, and high mortality [7]. As with patients in the first two decades of the HIV/AIDS epidemic, most patients with Chagas disease do not have access to health care facilities. A recent analysis indicates that many patients do not have access to the essential medicines for Chagas disease, in particular, the first line of therapy, the drug benznidazole [12]. According to Médecins Sans Frontières (MSF, Doctors Without Borders), many highly endemic countries, including Paraguay and Bolivia, face acute shortages of benznidazole, forcing thousands of newly diagnosed patients to postpone treatment [12]. Both diseases are also highly stigmatizing, a feature that for Chagas disease further complicates access to benznidazole and other essential medicines, as well as access to serodiagnosis and medical counseling. For some individuals with T. cruzi living in the US, immigration status presents an additional challenge to seeking care and prevention services. Just as stigma due to sexual orientation has been a barrier to HIV care and prevention, especially in the beginning of the epidemic, immigration status may function as a deterrent to Chagas disease care and prevention.

Based on the assertions outlined above—the chronic morbidities and high mortalities, the prolonged and expensive treatment courses, the lack of therapeutic options, and barriers to access to essential medicines—a patient living with Chagas disease faces formidable challenges that resemble those faced by someone living with HIV/AIDS, especially the challenges that occurred in the early years of the HIV/AIDS epidemic. Shown in Table 1 is a quantitative comparison between people living with Chagas disease [2], [4], [6], [13], [14] and those living with HIV/AIDS in the LAC region and the Americas [13][17]. Briefly, the roughly 10 million people living with Chagas disease (including 2–5 million individuals with Chagasic cardiomyopathy) is comparable in number to the 1.6 million people living with HIV/AIDS in the LAC region and the 1–2 million living with HIV/AIDS in North America (including Mexico). However, based on current estimates, both the number of annual DALYs lost and the attributed deaths are about five times higher for HIV/AIDS. The morbidity and mortality estimates for both Chagas disease and HIV/AIDS are undergoing revision by the University of Washington Institute of Health Metrics and Evaluation.

10.1371/journal.pntd.0001498.t001Table 1

Comparison of Chagas disease versus HIV/AIDS.

DiseaseEstimated Number of Cases in LAC [Reference]Estimated Number of Cases in North America [Reference]Estimated DALYs in the Americas [Reference]Estimated Annual Deaths in the Americas [Reference]Countries Most Affected [Reference]Chagas disease8–9 million (2–5 million cases of Chagasic cardiomyopathy) [2]0.3–1.0 million in the US [4], [6]0.7 million [13]14,000 [14]Bolivia, Mexico, Colombia, Central America [2]HIV/AIDS1.6 million [15], [16]2.3 milliona[17]3.2 million [13]105,000a[15][17]Brazil, Mexico, Colombia, United States [15][17]a

The UNAIDS data for North America also includes Western and Central Europe. According to the US Centers for Disease Control and Prevention, at the end of 2008 an estimated 1.2 million people were living with HIV in the US [40].

There are additional parallels. Chagas disease has emerged as an important blood transfusion–related risk throughout the Americas just as HIV/AIDS did in the early 1980s, prior to the implementation of widespread blood screening and testing [18][20]. Moreover, mother-to-child transmission leading to congenital Chagas disease and other adverse neonatal outcomes is increasingly recognized [21][24] (Table 2). Both congenital Chagas disease and HIV/AIDS have a recognized clinical syndrome [21], [25], with adverse birth outcomes as well as deleterious maternal effects in pregnancy [22], [23], [26]. During pregnancy, the rate of vertical transmission of T. cruzi infection is approximately 5% (although some investigators believe the rate could be as high as 10%), whereas it is 15%–40% for untreated HIV/AIDS [27] and 1%–2% for mothers who receive antiretroviral therapy [28]. The Pan American Health Organization estimates that there are over 14,000 cases of congenital Chagas disease in Latin America [29], with 2,000 newborns infected annually in North America alone [24], compared to 36,000 pediatric HIV/AIDS cases in Latin America [15].

10.1371/journal.pntd.0001498.t002Table 2

Comparison of congenital Chagas disease and HIV/AIDS.

CategoryCongenital Chagas Disease [Reference]Congenital HIV/AIDS [Reference]Major clinical featuresHepatosplenomegaly, hydrops, neonatal death [21].Failure to thrive, opportunistic infections, lymphocytic interstitial pneumonitis, developmental delays [25].Effects in pregnancyPregnancy enhances parasitemia [22]. Increased risk of miscarriage, preterm birth, neonatal infection [23].Increased spontaneous abortion, chorioamnionitis, low birth weight, prematurity [26].Vertical transmissionVertical transmission of 5% from seropositive mothers [23], although some investigators believe the transmission rate may be higher.Vertical transmission of 15%–40% without maternal treatment [27]. Vertical transmission of 1%–2% on antiretroviral treatment [28].Number of cases14,000 cases in Latin America [29]. 40,000 pregnant women in North America, 2,000 newborns are infected annually [24].36,000 pediatric HIV/AIDS cases in Central and South America [15].

It is only appropriate to point out that there are important differences between Chagas disease and HIV/AIDS. Whereas HIV/AIDS is almost always a fatal condition in the absence of antiviral therapy, up to 70%–80% of people with Chagas disease do not progress to cardiomyopathy. Moreover, Chagas disease is a true NTD and there is a paucity of anti-protozoan drugs available for this condition, whereas HIV/AIDS can no longer be considered neglected in this sense as there is an armamentarium of antiretroviral drugs currently available (although for both conditions, patients in developing countries suffer from lack of access to essential medicines). As another contrast between the two diseases, there is also evidence for oral transmission of Chagas through food contamination in the Amazon basin [30].

Over the last three decades of the global HIV/AIDS pandemic, an aggressive and committed activist community has achieved success in promoting widespread access to antiretroviral drugs in developed and developing countries. As a result, at present millions of people living with HIV/AIDS receive antiretroviral therapy, and pediatric HIV/AIDS has been nearly eliminated as a public health problem in the US [31]. Patient advocacy and global efforts to promote access to benznidazole and other therapies for Chagas disease, on the other hand, are at a much earlier stage. In the last decade, MSF has launched efforts to screen more than 80,000 people in Bolivia, Colombia, Guatemala, Honduras, Nicaragua, and Paraguay, having diagnosed and treated more than 6,000 and 4,000 individuals, respectively [12]. Other non-governmental organizations have also been engaged in Chagas disease treatments. Of great concern is a looming shortage of benznidazole, as well as the over-reliance on a single drug manufacturer, and inadequate international efforts to organize global production and distribution of the drug in Latin America [12]. Nifurtimox, another drug commonly used in the treatment of Chagas disease, should also be made available for the LAC region.

In parallel with global advocacy efforts, expansion of operational research activities is crucial to optimize the efficacy of existing control and elimination efforts, including the testing of more field-adapted tools [12]. There are also requirements to expand vector control activities and health education in the communities affected by Chagas disease, in addition to providing training for local health care providers in endemic areas [12]. The importance of a research and development agenda to develop new and improved Chagas disease drugs cannot be overlooked. As noted above, both antitrypanosomal drugs used for the treatment of Chagas disease, benznidazole and nifurtimox, require prolonged and expensive treatment courses; moreover, the efficacy of either drug for the treatment of late chronic infection and Chagasic cardiomyopathy still remains uncertain and unproven [32], [33]. Toxicities and the frequency of side effects of both medicines frequently require patients to interrupt or halt treatments, and both drugs are contraindicated in pregnancy [34][36]. In response to this crisis, the product development partnership (PDP) Drugs for Neglected Diseases initiative (DNDi) is accelerating the development of new Chagas disease drugs in the non-profit sector, in parallel with a small group of academic laboratories that are pursuing several drug targets [37], [38]. Finally, just as the International AIDS Vaccine Initiative (IAVI) PDP is developing several experimental HIV/AIDS vaccines, the Sabin Vaccine Institute PDP is accelerating the development of a new therapeutic Chagas disease vaccine in collaboration with several key universities and public sector biotechnology and manufacturing institutions in Mexico [1]. In further support of this research, a recent analysis by Lee and his colleagues confirms the potential cost effectiveness of Chagas disease vaccines [39].

Stark similarities exist between today's global Chagas disease epidemic and the first two decades of the HIV/AIDS epidemic. This translates into a humanitarian catastrophe for the poorest people in the Americas and elsewhere. This perceptible health disparity demands urgent attention by global health policy makers to prioritize Chagas disease and develop a comprehensive strategy for control and elimination efforts, blood screening and point-of-care testing, maternal and child interventions, health education, and parallel research and development. Successfully addressing the vast burden of Chagas disease will require overcoming the current lack of available drugs, together with expanding vector control strategies and developing new and innovative control tools. To this end, eliminating Chagas disease will require a commitment from international health agencies, governments of the disease-endemic countries, PDPs, and patient advocacy groups.


  1. PJ HotezE DumonteilMJ HeffernanME Bottazzi2012Innovation for “the bottom 100 million”: eliminating neglected tropical diseases in the Americas through mass drug administration and new vaccines for hookworm and Chagas disease.Adv Exp Med BiolIn press
  2. PJ HotezME BottazziC Franco-ParedesS AultMR Periago2008The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination.PLoS Negl Trop Dis2e300doi:10.1371/journal.pntd.000030018820747
  3. J GasconC BernMJ Pinazo2010Chagas disease in Spain, the United States, and other non-endemic countries.Acta Trop115222719646412
  4. PJ Hotez2008Neglected infections of poverty in the United States of America.PLoS Negl Trop Dis2e256doi:10.1371/journal.pntd.000025618575621
  5. C BernS KjosMJ YabsleySP Montgomery2011Trypanosoma cruzi and Chagas' disease in the United States.Clin Microbiol Rev2465568121976603
  6. C BernSP Montgomery2009An estimate of the burden of Chagas disease in the United States.Clin Infect Dis49e52e5419640226
  7. A Rassi JrA RassiJA Marin-Neto2010Chagas disease.Lancet3751388140220399979
  8. Pan American Health Organization-World Health Organization2007Health in the Americas 2007; Regional, scientific, and technical publication 622Washington (DC)Pan American Health Organization
  9. JA Marin-NetoE Cunha-NetoBC MacielMV Simoes2007Pathogenesis of chronic Chagas heart disease.Circulation1151109112317339569
  10. AL De AndradeF ZickerRM de OliveiraS Almeida SilvaA Luguetti1996Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection.Lancet348140714138937280
  11. M Castillo-RiqueimeF GuhlB TurriagoN PintoF Rosas2008The costs of preventing and treating Chagas disease in Colombia.PLoS Negl Trop Dis2e336doi:10.1371/journal.pntd.000033619015725
  12. Medécins Sans Frontières (MSF)2011The shortage of benznidazole leaves thousands of Chagas patients without treatment.Briefing Document, October 2011
  13. World Health Organization2004Annex table 3. Burden of disease in DALYs by cause, sex and mortality stratum in WHO regions, estimates for 2002.In: The world health report 2004. Available: Accessed 2 October 2011
  14. World Health Organization2004Annex table 2. Deaths by cause, sex and mortality stratum in WHO regions, estimates for 2002.In: The world health report 2004. Available: Accessed 2 October 2011
  15. UNAIDS.Fact sheet: Central and South America. Available: Accessed 2 October 2011
  16. UNAIDS.Fact sheet: Caribbean. Available: Accessed 2 October 2011
  17. UNAIDS.Fact sheet: North America and Western Europe. Available: Accessed 2 October 2011
  18. C YoungP LosikoffA ChawlaL GlasserE Forman2007Transfusion-acquired Trypanosoma cruzi infection.Transfusion4754054417319837
  19. HA PerkinsMP Busch2010Transfusion-associated infections: 50 years of relentless challenges and remarkable progress.Transfusion502080209920738828
  20. Y JacksonL GetazH WolffM HolstA MaurisA Tardin2010Prevalence, clinical staging and risk for blood-borne transmission of Chagas disease among Latin American migrants in Geneva, Switzerland.PLoS Negl Trop Dis4e592doi:10.1371/journal.pntd.000059220126397
  21. RN TheilerSA RasmussenTA TreadwellDJ Jamieson2008Emerging and zoonotic infections in women.Infect Dis Clin North Am22755772; vii–viii18954762
  22. R Siriano L daAO LuguettiJB AvelarNL MarraAM de Castro2011Chagas disease: increased parasitemia during pregnancy detected by hemoculture.Am J Trop Med Hyg8456957421460012
  23. FR Perez-LopezP Chedraui2010Chagas disease in pregnancy: a non-endemic problem in a globalized world.Arch Gynecol Obstet28259559920559648
  24. P BuekensO AlmendaresY CarlierE DumonteilM Eberhard2008Mother-to-child transmission of Chagas disease in North America: why don't we do more?Matern Child Health J1228328617602289
  25. AF Camacho-GonzalezAC RossR Chakraborty2010The clinical care of the HIV-1-infected infants.Clin Perinatol3787388521078456
  26. RW RyderM Temmerman1991The effect of HIV-1 infection during pregnancy and the perinatal period on maternal and child health in Africa.AIDS5Suppl1S75S851669928
  27. ML Newell2001Prevention of mother-to-child transmission of HIV: challenges for the current decade.Bull World Health Organ791138114411799446
  28. N SiegfriedL van der MerweP BrocklehurstTT Sint2011Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection.Cochrane Database Syst Rev7CD00351021735394
  29. Pan American Health Organization, World Health Organization2006Estimación cuantitativa de la enfermedad de Chagas en las Américas (OPS/HDM/CD/425-06)
  30. B Beltrao HdeP Cerroni MdeDR FreitasAY PintoC Valente Vda2009Investigation of two outbreaks of suspected oral transmission of acute Chagas disease in the Amazon region, Para State, Brazil, in 2007.Trop Doct3923123219762577
  31. MG FowlerAR GableMA LampeM EtimaM Owor2010Perinatal HIV and its prevention: progress toward an HIV-free generation.Clin Perinatol3769971921078445
  32. JA Perez-MolinaA Perez-AyalaS MorenoMC Fernandez-GonzalezJ Zamora2009Use of benznidazole to treat chronic Chagas' disease: a systematic review with a meta-analysis.J Antimicrob Chemo6411391147
  33. JA Marin-NetoA Rassi JrCA MorilloA AvezumSJ Connolly2008Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas cardiomyopathy: the BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT).Am Heart J156374318585495
  34. V Sarli IssaE Alcides Bocchi2010Antitrypanosomal agents: treatment or threat?Lancet37676876920816538
  35. M-J PinazoJ MunozE PosadaP Lopez-ChejadeM Gallego2010Tolerance of benznidazole in treatment of Chagas' disease in adults.Antmicrob Agents Chemotherap5448964899
  36. R ViottiC ViglianoB LococoMG AlvarezM Petti2009Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities.Expert Rev Anti-infective Therap7157163
  37. W Apt2010Current and developing therapeutic agents in the treatment of Chagas disease.Drug Design, Develop Ther4243253
  38. FS BucknerN Navabi2010Advances in Chagas disease drug development: 2009–2010.Curr Op Infect Dis23609616
  39. BY LeeKM BaconDL ConnorAM WilligRR Bailey2010The potential economic value of a Trypanosoma cruzi (Chagas disease) vaccine in Latin America.PLoS Negl Trop Dis4e916doi:10.1371/journal.pntd.000091621179503
  40. Centers for Disease Control and Prevention2011HIV Surveillance–United States, 1981–2008.MMWR Morb Mortal Wkly Rep6021689693Available: Accessed 21 October 201121637182

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